diff --git a/config/asdf/python-packages b/config/asdf/python-packages
deleted file mode 100644
index 377042c..0000000
--- a/config/asdf/python-packages
+++ /dev/null
@@ -1,4 +0,0 @@
-ansible
-pipenv
-neovim
-libtmux
diff --git a/scripts/install-pip-packages.md b/scripts/install-pip-packages.md
deleted file mode 100644
index ee818f4..0000000
--- a/scripts/install-pip-packages.md
+++ /dev/null
@@ -1,11 +0,0 @@
-# install-pip-packages
-
-Installs Python packages from `config/pip/packages` using `pip`.
-
-## Usage
-
-```bash
-scripts/install-pip-packages.sh
-```
-
-The script uses `pip install --user` for each package entry.
diff --git a/scripts/install-pip-packages.sh b/scripts/install-pip-packages.sh
deleted file mode 100755
index b355016..0000000
--- a/scripts/install-pip-packages.sh
+++ /dev/null
@@ -1,41 +0,0 @@
-#!/usr/bin/env bash
-# @description Install python/pip packages.
-#
-# shellcheck source=shared.sh
-source "${DOTFILES}/config/shared.sh"
-
-# Enable verbosity with VERBOSE=1
-VERBOSE="${VERBOSE:-0}"
-
-msgr run "Starting to install pip packages"
-
-if ! command -v python3 &> /dev/null; then
-  msgr err "Could not find python3, something really weird is going on."
-  exit 1
-fi
-
-msgr nested "Upgrading pip"
-python3 -m pip install --user --upgrade pip
-
-packages=(
-  "pipx"
-  "libtmux"
-)
-
-# Function to install pip packages
-install_packages()
-{
-  for pkg in "${packages[@]}"; do
-    # Trim spaces
-    pkg=${pkg// /}
-    # Skip comments
-    if [[ ${pkg:0:1} == "#" ]]; then continue; fi
-
-    msgr nested "Installing pip package: $pkg"
-    python3 -m pip install --user --upgrade "$pkg"
-    echo ""
-  done
-}
-
-install_packages
-msgr run_done "Run pip package installations"
diff --git a/scripts/install-python-packages.md b/scripts/install-python-packages.md
new file mode 100644
index 0000000..379bdb6
--- /dev/null
+++ b/scripts/install-python-packages.md
@@ -0,0 +1,18 @@
+# install-python-packages
+
+Install Python packages defined in the script using `uv`.
+
+## Usage
+
+```bash
+scripts/install-python-packages.sh
+```
+
+## What it does
+
+1. Checks that `uv` is available; if missing, installs it via the official installer.
+2. Installs each CLI tool from the inline `tools` array using `uv tool install --upgrade`.
+3. Installs each library from the inline `libraries` array using `uv pip install --system --upgrade`.
+4. Upgrades all uv-managed tools with `uv tool upgrade --all`.
+
+To add or remove packages, edit the `tools` or `libraries` arrays in `scripts/install-python-packages.sh`.
diff --git a/scripts/install-python-packages.sh b/scripts/install-python-packages.sh
new file mode 100755
index 0000000..801e487
--- /dev/null
+++ b/scripts/install-python-packages.sh
@@ -0,0 +1,77 @@
+#!/usr/bin/env bash
+# @description Install Python packages using uv.
+#
+# shellcheck source=shared.sh
+source "$DOTFILES/config/shared.sh"
+
+# Enable verbosity with VERBOSE=1
+VERBOSE="${VERBOSE:-0}"
+
+msgr run "Starting to install Python packages"
+
+# Ensure uv is available
+if ! command -v uv &> /dev/null; then
+  msgr nested "uv not found, installing via official installer"
+  curl -LsSf https://astral.sh/uv/install.sh | sh
+  export PATH="$HOME/.local/bin:$PATH"
+fi
+
+# CLI tools — installed isolated with `uv tool install`
+tools=(
+  ansible    # IT automation and configuration management
+)
+
+# Library packages — installed into system Python with `uv pip install --system`
+libraries=(
+  libtmux    # Python API for tmux
+  pynvim     # Neovim Python client
+)
+
+# Function to install CLI tools via uv tool install
+install_tools()
+{
+  msgr run "Installing Python CLI tools"
+  for pkg in "${tools[@]}"; do
+    # Strip inline comments and trim whitespace
+    pkg="${pkg%%#*}"
+    pkg="${pkg// /}"
+    [[ -z "$pkg" ]] && continue
+
+    msgr nested "Installing tool: $pkg"
+    uv tool install --upgrade "$pkg"
+    echo ""
+  done
+}
+
+# Function to install library packages via uv pip install
+install_libraries()
+{
+  msgr run "Installing Python libraries"
+  for pkg in "${libraries[@]}"; do
+    # Strip inline comments and trim whitespace
+    pkg="${pkg%%#*}"
+    pkg="${pkg// /}"
+    [[ -z "$pkg" ]] && continue
+
+    msgr nested "Installing library: $pkg"
+    uv pip install --system --upgrade "$pkg"
+    echo ""
+  done
+}
+
+# Function to upgrade all uv-managed tools
+upgrade_tools()
+{
+  msgr run "Upgrading all uv-managed tools"
+  uv tool upgrade --all
+}
+
+main()
+{
+  install_tools
+  install_libraries
+  upgrade_tools
+  msgr yay "Python package installations complete"
+}
+
+main "$@"